Winners and nominees. The nominees for the 65th Academy Awards were announced on February 17, 1993, at the Samuel Goldwyn Theater in Beverly Hills, California, by Robert Rehme, president of the Academy, and actress Mercedes Ruehl. Howards End and Unforgiven led all nominees with nine nominations each.. The winners were announced during the awards ceremony on March 29, 1993.Retinal pigment epitheliumspecific 65 kDa protein, also known as retinoid isomerohydrolase, is an enzyme of the vertebrate visual cycle that is encoded in humans by the RPE65 gene. RPE65 is expressed in the retinal pigment epithelium (RPE, a layer of epithelial cells that nourish the photoreceptor cells) and is responsible for the conversion of alltransretinyl esters to 11cisretinol ...
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